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LOUIS — For three generations, the Plunge, an award-winning dive bar and restaurant in Northeast St. Louis that is on track to close for good in September, has been a safe haven for the city's LGBTQ population. The owners of the bar, Chris Raous, Lisa Cox and Michael Crowley, also made sure the bar's staff was safe places for people of color and trans folks. "It was a diverse dive bar," Raous said. "It was a safe haven." But now it may be closing. And so could many of the areas' historical LGBTQ hot spots. Though the city has not yet chosen a single commercial property to be demolished and replaced, with gentrification in full swing, it's a trend that's plaguing the neighborhood. The Plunge is on the border of the city's Ground Zero historic district. Its landlord of the building, Youngstown-based Saw Creek Investment Group, filed for an eviction notice earlier this year and has rejected nearly three dozen rent increases as the business has struggled to stay in operation. That's what forced the trio to sign a lease just last month, even as Saw Creek was trying to evict them. They have been negotiating with the landlord ever since, with no success. "I'm very close to letting them go," a flustered Crowley told WGEM on Friday afternoon, before the station stopped calling by dinnertime. He and Cox said they'd rather close on their own terms, rather than have an eviction. But they've been hit with a series of unexpected expenses. St. Louis Mayor Lyda Krewson on Friday also made it clear that the City Council plans to vote on July 9 on allowing some commercial buildings to be demolished as part of urban renewal projects, adding that Saw Creek Investment Group is simply "the unfortunate party" in this. "The public should not have to foot the bill for these kinds of discriminatory actions," Krewson told WGEM. It's unclear what will happen to the Plunge and the nearby Black Dog Tavern if Saw Creek's plans are approved. It's also unclear what other LGBTQ businesses will have to leave St. Louis. Crowley said the plans include tearing down his home on South 21st Street and replacing it with a mix of condos and student housing. All the businesses being pushed out are "truly places where you can go, have food What's New In? ](#key280-T3){ref-type="table"}). It may seem strange that there were no consistent end-points at which the standard meta-analyses diverged from the adjusted indirect comparison. Perhaps it would have been informative to estimate the effect of different levels of perinatal mortality on neonatal mortality. However, death was not an outcome in all trials of antenatal steroids with reported mortality. Furthermore, the relationship between neonatal mortality and perinatal mortality is unclear. Finally, in the studies with a comparison between antenatal steroids and placebo, few neonatal deaths were observed, and in this situation the meta-analyses with the different statistical approaches performed very similarly \[[@key280-B16]\]. Overall, the effect of perinatal mortality on adjusted indirect comparisons and the standard meta-analyses are similar, indicating that it is appropriate to model the relationship between outcome and treatment with a logistic regression or marginal structural model as part of the indirect comparison methodology. Our results also showed that there was little difference in efficacy between different routes of administration (nasal and intravenous) in reducing neonatal mortality. This is perhaps unsurprising as it has long been known that premature infants respond well to antimicrobial therapy; hence it may be expected that the route of administration would not have a major impact on efficacy \[[@key280-B19]\]. There was an increased efficacy of nebulized and intravenous steroids in reducing neonatal mortality, suggesting that these routes of administration were more effective than nasal steroids. The results for primary neonatal morbidity were more variable with smaller effects for both routes of administration, and a greater reduction of intraventricular haemorrhage with intravenous steroids than for nebulized steroids. Perhaps this suggests that intravenous steroids are particularly effective for a small number of neonatal morbidities, although the extent to which the effects of steroids are determined by treatment-related or unmeasured factors cannot be determined from these results. The indirect comparison methodology relies on the assumption that all study participants are exposed to the same risk of the outcome, and that the comparison is made without differential bias. The principal advantage of the adjusted indirect comparison approach over standard meta-analyses is the opportunity to directly adjust for selection bias by using the hazard ratio for each treatment group from a Cox proportional hazards model of survival. This does not take into account any differences between the indirect and direct comparison treatment effects in terms of the underlying risk of the outcome, which is System Requirements: Minimum: Processor: 2 GHz Memory: 2 GB RAM Hard Disk: 40 GB Graphics Card: NVIDIA GeForce 9600M DirectX: Version 11 Additional Notes: Installation can take a couple of hours. Be prepared for this. Recommended: Memory: 4 GB RAM Additional Notes: Installation can take a couple of hours. Be prepared
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